CLINCHED PLAYOFF BERTH: CF Montréal, New York City FC, New York Red Bulls, Philadelphia Union
ELIMINATED FROM PLAYOFF CONTENTION: Atlanta United FC, Chicago Fire FC, D.C. United, New England Revolution, Toronto FC
Orlando City SC (45 points, 13-13-6)
Orlando City SC clinches Audi 2022 MLS Cup Playoffs berth with:
- Orlando City SC WIN at Inter Miami CF AND Columbus Crew LOSS at Charlotte FC
Inter Miami CF (45 points, 13-13-6)
Inter Miami CF clinches Audi 2022 MLS Cup Playoffs berth with:
- Inter Miami CF WIN vs. Orlando City SC
Charlotte FC (41 points, 13-17-2)
Charlotte FC eliminated from Audi 2022 MLS Cup Playoffs contention with:
- Charlotte FC LOSS/DRAW vs. Columbus Crew
